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Lifelong best friends Alexa and Katie are eagerly anticipating the start of their freshman year of high school. The pals confront a crisis that leaves them feeling like outsiders at a time when what seems to matter most is fitting in.
“Friendship is the best medicine.”
2018
Sophomore year is off to a good start for the girls until Katie twists her ankle. That gives Alexa something else to focus on while waiting to hear from her doctor.
Katie is thrilled when chosen to study acting in London. But the $2,000 tuition is way out of her financial range. So she takes on a series of odd jobs trying to come up with the money to send her to the UK.
Katie applies for a job at the coffee shop without telling her mom. When Lucas and Gwenny go out on a date, the girls are determined to sabotage it.
Alexa gets the doctor's OK to play basketball but struggles on the court. A heart-to-heart with another young cancer patient reminds her of how far she has come.
When Alexa and Dylan get into a fight right before the big Halloween party, Katie's sure she can fix it. But what if they're not meant to be together?
Alexa claims she's fine -- so the girls take her shopping for a Sweet 16 dress. Back at the house, a stressed-out Lucas goes to Dave for dating advice.
When Katie needs help prepping for a math midterm, Alexa offers to ask Dylan. Meanwhile, Jennifer still doesn't know her daughter has a job.
Alexa's working overtime to keep Christmas on track. But finding her old hospital bag stirs up memories that throw her off her holiday game.
It's New Year's Eve, and a bold new Katie is finally ready to confess her feelings for Ryan. Cue the fireworks -- and a flaming espresso machine!
An expensive mistake means Katie can't afford to go to London. But she's keeping it a secret so she doesn't ruin Alexa's epic birthday party.
2018
Alexa's plan to hide her cancer from her classmates and start high school like everyone else is totally doable ... until she starts losing her hair.
The girls come up with a colorful solution to keep Alexa's diagnosis under wraps. But Dave's having trouble adjusting to his daughter's new look.
There's a rumor going around school that someone in the class has cancer. Katie tries out for the basketball team, and Lori starts working from home.
Alexa goes out of her way to prove she can't be punished. Jennifer surprises Jack with a backyard campout but has a hard time getting him to unplug.
After landing the lead in the school play, Katie's left wondering whether she actually earned it. Jennifer asks Lucas to baby-sit.
Now that Alexa's secret is out, everyone's being unbearably nice -- even Gwenny. Jennifer and Jack invite themselves over to watch the World Series.
To kiss or not to kiss? Katie's new life as a thespian has Alexa feeling a little left out. Jennifer accuses Lori of stealing her thunder.
Alexa's got such a great support system at the hospital that Katie isn't sure where she stands. Lori pours her anxieties into baking.
The doctors order Alexa to stay home, but she can still come to school -- on an iPad. Jennifer works overtime to convince Jack her job is cool.
Alexa insists on cooking Thanksgiving dinner, but Lori has trouble letting go. Katie's desperate to connect with her dad on a deeper level.
Dave can't wait to show Lucas his alma mater. And with her family away for the weekend, Alexa's ready to break all the rules.
Lucas longs for "bro time" now that Dylan and Alexa are hanging out. Dave's nose detects a cat ... and he's not wrong.
Alexa's first high school dance is right around the corner. But a risky flu outbreak means she might not be able to go.
2019
A big fight on the first day of school leaves the girls feeling way out of sync. Lucas starts college, and Lori and Dave toast their 20th anniversary.
Alexa's ready to leave cancer behind her, but it's not that simple. Meanwhile, Katie's trying to balance all the things -- and it's super complicated.
Being there for Spencer brings back memories Alexa would rather forget. Katie looks for leadership opportunities, and Jennifer preps for a date.
Katie and Ryan don't feel the same way about each other anymore, but neither has the heart to say it. Alexa's determined to pass her driver's test.
Alexa's excited to see Dylan again but senses Spencer needs her more. Katie organizes a food drive, and Dave goes overboard on holiday decorating.
Katie aims high to win a community theater competition, putting unnecessary pressure on her friends -- and herself. Lucas reexamines his future.
Alexa struggles to keep her "real" life -- and her life with Spencer -- separate. A horrified Katie's convinced that her mom is dating Gwenny's dad.
Alexa takes Katie miniature golfing to get her mind off the SATs. Lori plays matchmaker when Jennifer hires a handsome handyman.
2020
Alexa eases Katie's anxiety with an epic plan to crush senior year. Jennifer starts her new job, and Jack and Lucas help solve each other's problems.
Alexa's full of advice after getting her driver's license — but she doesn't know everything. Meanwhile at Wired, the new hire is Katie's worst nightmare.
After dating Joe for six months, Jennifer's ready for him to meet her family and friends. It's just dinner ... but Katie's got some concerns.
With college applications looming, an aptitude test reveals Katie's true passion. But pursuing it is scary — and Alexa's "dream job" doesn't feel right.
Alexa agrees to speak at Lori's carnival-themed Stand Up to Cancer fundraiser, where Katie's coffee kiosk brews unexpected jealousy.
College acceptance letters are here. But did Alexa and Katie get into the same school? And why are things suddenly so weird between Alexa and Spencer?
Senior prom is on Saturday, and Katie needs a date. (See also: the courage to tell Alexa something important.) Lori and Joe go overboard at game night.
The girls are finally graduating from high school and getting ready to leave home for college. But will they stay together or go their separate ways?
Paris Berelc
Alexa Mendoza
Isabel May
Katie Cooper
Tiffani-Amber Thiessen
Lori Mendoza
Emery Kelly
Lucas Mendoza
Finn Carr
Jack Cooper
Eddie Shin
Dave Mendoza
Jolie Jenkins
Jennifer Cooper
