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A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.
“Solve the puzzle. Save the patient.”
2025
Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders six months after the death of his friend and partner, Sherlock Holmes, at the hands of Moriarty.
Watson and the fellows investigate the perplexing case of a family man with a bullet lodged in his head who insists he is a Scottish soldier and seems to be hiding something nefarious.
Watson and the fellows treat a comedian who collapses at an open mic night, but throughout the case her past is revealed to be much more complex than initially believed.
When Sasha discovers a link between her current patient, who has advanced cancers and distinctive lesions on his tongue indicative of Cowden syndrome, and a cadaver she dissected during medical school, the team traces the case to Amish country.
Watson takes a major ethical risk when he decides to treat a sickle cell patient with an unorthodox surgery, and the team faces their own dilemma when they must decide whether to look the other way or help the young woman.
Stephens musters the courage to ask Watson to help him when his camgirl suddenly collapses during a video call. He does not know anything about her real life, so the team must act quickly to locate her before it's too late.
While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline. Also, Moriarty plots his next move.
Watson runs into brilliant con artist and an old friend of Sherlock Holmes, Irene Adler, when her son Angus is admitted to UHOP for temporary paralysis. The fellows help Watson after he grows fond of Angus and pursue various leads to find a cure to his illness.
Ingrid's lies come back to haunt her when her sister Gigi needs to be treated by the team after she develops side effects to the secret treatments Ingrid put her through. Also, Watson and Mary bond over a tragedy.
Watson is thrown into a detective case when he is unsure whether the patient he is treating for one of the most rare ailments in the world, Alien Hand Syndrome, is guilty of pushing his brother in front of a bus to his death.
Watson confronts a traumatic event from his Army days that still weighs heavily on him when his Army veteran friend’s wife reaches out begging for help when her husband is seemingly having a psychotic break. Meanwhile, Shinwell is asked for one last favor by Moriarty.
When part of the team falls ill after becoming targets of a sinister plot, it becomes an all-hands-on-deck situation to save them before it's too late. Meanwhile, Watson announces a new ambitious project that he has been working on.
Watson and the team are faced with an impossible choice when two lives hang in the balance, but they only have one vial of antidote available. Meanwhile, Shinwell races to help the team, and Watson goes head to head with Moriarty.
2025
Watson and the fellows spring back into action when Mary’s mother accidentally poisons herself while suffering from a rare form of dementia that is progressing with impossible speed. Meanwhile, Sherlock Holmes resurfaces after being presumed dead.
A microbiology researcher returns from an expedition to Siberia, leading to a possible outbreak of a revived pathogen. Watson reconnects with Sherlock Holmes.
Watson and the team work alongside Laila to help a patient named Maxine, a 30-year-old who looks 10 years old.
Watson and the team jump into action when four new patients are brought to UHOP with wounds that appear to be infected with a flesh-eating bacterium following a tornado. Meanwhile, Shinwell searches for meaning as a nursing student and Adam’s wedding to Lauren risks being halted.
While visiting another hospital, Watson becomes convinced that a coma patient is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade. After the patient is transferred to UHOP for treatment, he shocks the team with chilling messages. Meanwhile, Sherlock is back in town and is staying with Watson.
Watson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer. Meanwhile, Mycroft Holmes lets Watson know his team’s work at UHOP may no longer have funding available.
Watson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts. As Annabelle's condition worsens, Watson must confront his long-standing tensions with his father in order to save her.
UHOP veers into terror when Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter’s illness.
Watson and the fellows help Laila’s son Micah – who was injured in a car accident while pursuing his crush, Bex, with the help of his AI chatbot.
Watson’s biohacker friend Hobie returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong. Meanwhile, Watson becomes suspicious of Sherlock.
Watson and the fellows race against the clock to save a man and his pregnant wife from a terrifying sinkhole. Meanwhile, Ingrid’s future with her therapy group becomes unclear.
When a patient arrives at the Holmes Clinic plagued by a mysterious neurological disorder, Watson and the fellows discover they were forced to eat their parents amid a childhood survival incident. Meanwhile, Adam is struggling with how his future will change as a father.
Watson and the fellows fight to revive a 30-year-old woman, Audrey, after her heart inexplicably stops repeatedly until they discover she has a rare phenomenon called Lazarus syndrome. As these revivals continue, she uses the short window of time available to right her greatest wrong.
Watson is sued for Wrongful Life by a long-term patient suffering from VACTERL association, after undergoing multiple painful surgeries.
Watson and the fellows race to save the life of a young woman who needs a lifesaving kidney donation. Meanwhile, Sherlock returns to help crack unsolved cases in Pittsburgh.
Watson investigates a case involving a mentally unstable mother, with the woman's delusions serving as a mirror to his own newly discovered hallucinations.
In the wake of the car accident, Watson and Laila lie injured and awaiting rescue as the team races to find them before it’s too late. Meanwhile, in a state between life and death, Watson’s mind plays out a modern-day investigation of a case that has long haunted him.
Following his brain tumor diagnosis, Watson goes on medical leave to seek treatment, leaving Mary in charge of The Holmes Clinic as a notorious South American dictator demands Watson see to his mysterious autoimmune condition personally. Meanwhile, Ingrid grows more concerned about Beck’s obsession with Sasha.
As Adam's wife goes in for a C-section to deliver triplets, chaos ensues when their OB-GYN passes out in the operating room. Meanwhile, a severe storm detours Watson and Mary's trip to find a renowned doctor to remove Watson's brain tumor.
A seemingly random murder outside of UHOP sets the stage for the arrival of someone from Watson and Sherlock Holmes' past.
Morris Chestnut
Dr. John Watson
Eve Harlow
Dr. Ingrid Derian
Peter Mark Kendall
Dr. Stephens Croft / Dr. Adam Croft
Inga Schlingmann
Dr. Sasha Lubbock
Ritchie Coster
Shinwell Johnson
Rochelle Aytes
Dr. Mary Morstan
